Fig. 1 · Structure

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Retrocyclin-1

θ defensin

Retrocyclin-1 is a θ defensin that primarily targets carbohydrate-containing surface molecules. This cyclic peptide demonstrates potent antiviral activity by inhibiting HIV-1 infection through its high-affinity binding to key cellular targets, including fetuin (Kd=35.4 nM), gp120 (Kd=31 nM), CD4 (Kd=31 nM), and galactosylceramide (Kd=24.1 nM). It serves as a valuable tool for research into antiviral therapies and the mechanisms of immune responses against viral infections.

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Specifications

Manufacturer Adooq Bioscience
CAS Number 724760-19-4
Applications θ defensin
Formula C74H128N30O18S6
Molecular Weight 1918.39
SMILES
O=C1[C@]2(NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@]3(NC(=O)[C@]([C@H](CC)C)(NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@](CSSC3)(NC(=O)[C@]([C@H](CC)C)(NC(=O)[C@](CSSC2)(NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@]4(CSSC[C@](NC(=O)[C@]([C@H](CC)C)(N1)[H])(C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@]([C@H](CC)C)(C(=O)N4)[H])[H])[H])[H])[H])[H])[H])[H])[H]

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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