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Fig. 1 · Structure
Cat. No.
A19905
CAS No.
313397-13-6
Formula
C26H27N5O2
Mol. Weight
441.52

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Reversan

Cat. No. A19905 CAS 313397-13-6

MRP1/Pgp inhibitor

Reversan (CBLC4H10) is a potent and nontoxic multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (Pgp) inhibitor.

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Biological Activity

Cellular Effect

Cell Line Activity Value Description Reference
A7R5 IC50 > 100 μM Antagonist activity at calcium channel in rat A7R5 cells assessed as inhibition of Cacl2/KCl-induced increase in intracellular Ca2+ incubated for 15 mins prior to Cacl2/KCl challenge by fluorescence assay [PMID: 25311564]
MES-SA EC50 18.4 μM Modulation of P-gp mediated drug efflux in human MES-SA cells assessed as accumulation of rhodamine-123 incubated for 15 mins prior to rhodamine-123 addition measured after 1 hr by fluorescence analysis [PMID: 25311564]
NCI-H69 EC50 9.8 μM Modulation of MRP1 mediated drug efflux in doxorubicin-resistant human H69 cells assessed as accumulation of calcein AM incubated for 15 mins prior to calcein AM addition measured after 30 mins by fluorescence analysis [PMID: 25311564]

Specifications

Manufacturer Adooq Bioscience
Actions Inhibitor
CAS Number 313397-13-6
Applications MRP1/Pgp inhibitor
Formula C26H27N5O2
Molecular Weight 441.52
Synonyms CBLC4H10
SMILES
O=C(C1=C2N(C(C3=CC=CC=C3)=CC(C4=CC=CC=C4)=N2)N=C1)NCCCN5CCOCC5

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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