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$0.00 - Hazheen K, .et al. BuGZ facilitates loading of spindle assembly checkpoint proteins to kinetochores in early mitosis, J Biol Chem, 2020, August 20
Biological Activity
Reversine is a potent human A3 adenosine receptor antagonist with Ki of 0.66 μM, and a pan-aurora A/B/C kinase inhibitor with IC50 of 12 nM/13 nM/20 nM, respectively. Also used for stem cell dedifferentiation.
Targets
| Aurora A | Aurora B | Aurora C | human A3 adenosine receptor | |
| 12 nM | 13 nM | 20 nM | 0.66 μM(Ki) |
| In vitro | DMSO | Warmed: 4 mg/mL (10.17 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 25.41 mL | 127.06 mL | 254.13 mL |
| 0.5 mM | 5.08 mL | 25.41 mL | 50.83 mL |
| 1 mM | 2.54 mL | 12.71 mL | 25.41 mL |
| 5 mM | 0.51 mL | 2.54 mL | 5.08 mL |
*The above data is based on the productmolecular weight 393.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A13250 |
|---|---|
| Actions | Inhibitor, Antagonist |
| CAS No. | 656820-32-5 |
| Formula | C21H27N7O |
| M. Wt | 393.5 |
| Solubility | DMSO |
| Purity | >98% |
| Synonyms | 0 |
| SMILES | C1CCC(CC1)NC2=NC(=NC3=C2NC=N3)NC4=CC=C(C=C4)N5CCOCC5 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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