Fig. 1 · Structure

Cat. No.: A13218
CAS No.: 1357389-11-7
Formula: C₂₁H₁₉FN₄O
Mol. Weight: 362.4

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Other Forms

Form	MW
RGFP966 This page	362.4
(E,E)-RGFP966	362.40

RGFP966

Name: RGFP966
Brand: Adooq Bioscience
SKU: A13218
Availability: InStock
Rating: 5 (1 reviews)

Cat. No. A13218 CAS 1357389-11-7

HDAC3 inhibitor

RGFP966 is an HDAC3 inhibitor with IC50 of 0.08 μM, exhibits > 200-fold selectivity over other HDAC.

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Biological Activity

Target & Activity

Target	Activity	Value
HDAC3	IC50	80 nM

Cellular Effect

Cell Line	Activity	Value	Description	Reference
HEL	IC50	1.64 μM	Antiproliferative activity against human HEL cells after 48 hrs in presence of JAK2 inhibitor CYT-387 by CCK-8 assay	[PMID: 29940115]
HEL	IC50	21.71 μM	Antiproliferative activity against human HEL cells after 48 hrs by CCK-8 assay	[PMID: 29940115]
HL-60	IC50	1.64 μM	Antiproliferative activity against human HL60 cells after 48 hrs in presence of JAK2 inhibitor CYT-387 by CCK-8 assay	[PMID: 29940115]
HL-60	IC50	21.71 μM	Antiproliferative activity against human HL60 cells after 48 hrs by CCK-8 assay	[PMID: 29940115]
K562	IC50	1.64 μM	Antiproliferative activity against human K562 cells after 48 hrs in presence of JAK2 inhibitor CYT-387 by CCK-8 assay	[PMID: 29940115]
K562	IC50	21.71 μM	Antiproliferative activity against human K562 cells after 48 hrs by CCK-8 assay	[PMID: 29940115]

Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	1357389-11-7
Applications	HDAC3 inhibitor
Formula	C₂₁H₁₉FN₄O
Molecular Weight	362.4
SMILES	C1=CC=C(C=C1)/C=C/CN2C=C(C=N2)/C=C/C(=O)NC3=C(C=C(C=C3)F)N

Storage & Solubility

In Vitro Solubility

Reported Solubility

Solvent	Reported Solubility
DMSO	70 mg/mL (193.15 mM)
Water	Insoluble
Ethanol	Insoluble

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

In Vivo Preparation

Concentration: 6.1 mg/mL
Vehicle: 5%DMSO+40%PEG300+10%Tween80+45%ddH2O

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Publications

1 publication citing this product

Vijaya Bharti, .et al. , Cell Rep, 2022, Dec 20;41(12):111826 PMID: 36543138