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RGH-857

Nicotinic α7 Positive Allosteric Modulator

RGH-857 acts as a selective and potent positive allosteric modulator of nicotinic α7 receptors. It demonstrates effectiveness in ameliorating amnesia and is valuable in studies related to Alzheimer's disease. This compound can facilitate research into cognitive impairment and potential therapeutic interventions in neurodegenerative disorders.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Modulator
CAS Number	2408754-53-8
Applications	Nicotinic α7 Positive Allosteric Modulator
Formula	C₂₁H₂₁F₃N₄O₅S
Molecular Weight	498.48
SMILES	COC1=C(C=C(C=C1)C2=NS(=O)(N(C(C(NC3=NC(C(F)(F)F)=CC=C3)=O)=C2)C(C)C)=O)OC

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.