Fig. 1 · Structure
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RH01386
ER Stress-Induced β Cell Dysfunction Prevention
RH01386 is a small molecule that targets endoplasmic reticulum stress to prevent β cell dysfunction and apoptosis. By inhibiting proapoptotic gene expression, RH01386 effectively restores glucose-stimulated insulin secretion impaired by ER stress. This compound holds potential for therapeutic applications in the treatment of type 2 diabetes.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 301177-36-6 |
| Applications | ER Stress-Induced β Cell Dysfunction Prevention |
| Formula | C18H15F3N4O3S |
| Molecular Weight | 424.40 |
| SMILES | N#CC1=C(C2CCCCC2)N=C(SC3=CC=C(C(F)(F)F)C=C3[N+]([O-])=O)NC1=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.