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RhlR antagonist 1

RhlR Antagonist

RhlR Antagonist 1 is a selective antagonist of the RhlR receptor with an IC50 of 26 μM. This compound demonstrates effective inhibition of biofilm formation under both static and dynamic conditions and reduces the production of virulence factors, including rhamnolipid and pyocyanin, in Pseudomonas aeruginosa. RhlR Antagonist 1 serves as a valuable tool for the development of quorum-sensing-modulating agents aimed at controlling P. aeruginosa infections. Additionally, it features a reactive alkyne group, enabling it to engage in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	2614320-29-3
Applications	RhlR Antagonist
Formula	C₁₂H₁₀F₂O
Molecular Weight	208.20
SMILES	CCCC(C#CC1=CC=C(F)C(F)=C1)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.