Fig. 1 · Structure
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RIDR-PI-103
ROS Activated Prodrug
RIDR-PI-103 is a reactive oxygen species (ROS)-activated prodrug that features a self-cyclizing moiety connected to a pan-PI3K inhibitor (PI-103). This compound exhibits significant synergistic effects in combination with doxorubicin, effectively inhibiting the proliferation of MDA-MB-361 and MDA-MB-231 breast cancer cells. Its unique mechanism provides a promising avenue for targeted cancer therapies and research applications focusing on ROS-mediated drug activation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2581114-71-6 |
| Applications | ROS Activated Prodrug |
| Formula | C27H25N7O4 |
| Molecular Weight | 511.53 |
| SMILES | O=C(CN)NC1=CC(N)=CC=C1OC2=CC=CC(C3=NC4=C(C(N5CCOCC5)=N3)OC6=NC=CC=C64)=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.