Fig. 1 · Structure
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Rilpivirine hydrochloride
NNRTI
Rilpivirine hydrochloride is a potent non-nucleoside reverse transcriptase inhibitor (NNRTI) targeting HIV-1. It exhibits significant antiviral activity against both wild-type HIV (EC50=0.4 nM) and various mutant strains (EC50=0.1-2.0 nM). Rilpivirine hydrochloride is characterized by its high genetic barrier to the development of resistance, making it a valuable tool for studying HIV treatment and resistance mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 700361-47-3 |
| Applications | NNRTI |
| Formula | C22H19ClN6 |
| Molecular Weight | 402.88 |
| Synonyms | TMC-278 hydrochloride |
| SMILES | N#CC1=CC=C(NC2=NC=CC(NC3=C(C)C=C(/C=C/C#N)C=C3C)=N2)C=C1.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.