Fig. 1 · Structure
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Rinzimetostat
PRC2 Inhibitor
Rinzimetostat is a selective allosteric inhibitor of the EED subunit of the polycomb repressive complex 2 (PRC2). This orally active compound exhibits significant potential in modulating gene expression through PRC2 inhibition, making it advantageous for studies involving epigenetic regulation. Its synergistic effects with androgen receptor pathway inhibitors (ARPIs) highlight its utility in researching metastatic prostate cancer and exploring novel therapeutic approaches.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2369769-29-7 |
| Applications | PRC2 Inhibitor |
| Formula | C26H25FN6O |
| Molecular Weight | 456.51 |
| Synonyms | ORIC-944 |
| SMILES | CC1=C(C=CC(CN(C)C)=C1)C2=CN=C(N3C=C(N=C23)C#N)NCC4=C(C=CC5=C4CCO5)F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.