Fig. 1 · Structure
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RIP1 kinase inhibitor 4
RIP1 Inhibitor
RIP1 kinase inhibitor 4 is a selective inhibitor of RIP1 kinase with an EC50 of less than 100 nM, demonstrating the ability to penetrate the blood-brain barrier. This compound is pertinent for research into necrosis-related diseases, aiding in the investigation of cell programming mechanisms. Additionally, RIP1 kinase inhibitor 4 features an alkyne group, making it suitable for click chemistry applications, specifically copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2919836-00-1 |
| Applications | RIP1 Inhibitor |
| Formula | C23H23N5 |
| Molecular Weight | 369.46 |
| SMILES | NC(N=C1)=NC=C1C#CC2CCC(C2)N3N=C4C(CCC4C5=CC=CC=C5)=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.