RIPK1-IN-38 is a potent, orally active inhibitor of receptor-interacting protein kinase 1 (RIPK1), with an IC50 value of 27 nM. It effectively blocks the phosphorylation of RIPK1 and its downstream effectors, RIPK3 and MLKL, thereby exhibiting significant anti-necroptotic activity. This compound demonstrates strong anti-inflammatory effects in models of systemic inflammatory response syndrome (SIRS) and graft-versus-host disease (GVHD). RIPK1-IN-38 is suitable for research into inflammatory and immune-related diseases.
RIPK1-IN-38 is a potent, orally active inhibitor of receptor-interacting protein kinase 1 (RIPK1), with an IC50 value of 27 nM. It effectively blocks the phosphorylation of RIPK1 and its downstream effectors, RIPK3 and MLKL, thereby exhibiting significant anti-necroptotic activity. This compound demonstrates strong anti-inflammatory effects in models of systemic inflammatory response syndrome (SIRS) and graft-versus-host disease (GVHD). RIPK1-IN-38 is suitable for research into inflammatory and immune-related diseases.
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