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Biological Activity
RIPK1-IN-7 is a potent and selective RIPK1 inhibitor with a Kd of 4 nM and an enzymatic IC50 of 11 nM. RIPK1-IN-7 exhibits excellent antimetastasis activity in the experimental B16 melanoma lung metastasis model.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.77 mL | 103.85 mL | 207.7 mL |
| 0.5 mM | 4.15 mL | 20.77 mL | 41.54 mL |
| 1 mM | 2.08 mL | 10.38 mL | 20.77 mL |
| 5 mM | 0.42 mL | 2.08 mL | 4.15 mL |
*The above data is based on the productmolecular weight 481.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A18940 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 2300982-44-7 |
| Formula | C25H22F3N5O2 |
| M. Wt | 481.47 |
| Purity | >98% |
| Synonyms | 0 |
| SMILES | NC1=C2C(N(CC)C=C2C3=CC(CCN4C(CC5=CC=CC(OC(F)(F)F)=C5)=O)=C4C=C3)=NC=N1 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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