RIPK3-IN-3 is a selective inhibitor of the receptor-interacting protein kinase 3 (RIPK3), with an IC50 of 10 nM. This compound effectively prevents the phosphorylation of Mixed Lineage Kinase (MLKL), thereby inhibiting oligomerization of p-MLKL and subsequently blocking necroptosis. Additionally, RIPK3-IN-3 has been shown to downregulate CXCL5 secretion and suppress migration and invasion in AsPC-1 cancer cells, making it a valuable tool for studying necroptosis and related pathways in cancer research.
RIPK3-IN-3 is a selective inhibitor of the receptor-interacting protein kinase 3 (RIPK3), with an IC50 of 10 nM. This compound effectively prevents the phosphorylation of Mixed Lineage Kinase (MLKL), thereby inhibiting oligomerization of p-MLKL and subsequently blocking necroptosis. Additionally, RIPK3-IN-3 has been shown to downregulate CXCL5 secretion and suppress migration and invasion in AsPC-1 cancer cells, making it a valuable tool for studying necroptosis and related pathways in cancer research.
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