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Biological Activity
Rislenemdaz (CERC-301) is an orally bioavailable and selective N-methyl-D-aspartate (NMDA) receptor subunit 2B (GluN2B) antagonist with Ki and IC50 of 8.1 nM and 3.6 nM, respectively.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 27.9 mL | 139.51 mL | 279.01 mL |
| 0.5 mM | 5.58 mL | 27.9 mL | 55.8 mL |
| 1 mM | 2.79 mL | 13.95 mL | 27.9 mL |
| 5 mM | 0.56 mL | 2.79 mL | 5.58 mL |
*The above data is based on the productmolecular weight 358.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A21907 |
|---|---|
| Actions | Antagonist |
| CAS No. | 808732-98-1 |
| Formula | C19H23FN4O2 |
| M. Wt | 358.41 |
| Purity | >98% |
| Synonyms | MK-0657, MK0657, MK 0657; CERC-301, CERC 301, CERC301 |
| SMILES | O=C(N1C[C@@H](F)[C@@H](CNC2=NC=CC=N2)CC1)OCC3=CC=C(C)C=C3 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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