Fig. 1 · Structure
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Risvodetinib
Tyrosine Kinase Inhibitor
Risvodetinib is a selective protein tyrosine kinase inhibitor that primarily targets c-Abl1 and c-Abl2/Arg with IC50 values of 33 nM and 14 nM, respectively. This orally active compound demonstrates significant efficacy in suppressing c-Abl activation, offering neuroprotective effects on dopaminergic neurons in mouse models of both inherited and sporadic Parkinson’s disease. Risvodetinib is a promising reagent for research focused on the mechanisms of Parkinson’s disease and potential therapeutic interventions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2031185-00-7 |
| Applications | Tyrosine Kinase Inhibitor |
| Formula | C33H34N8O2 |
| Molecular Weight | 574.68 |
| Synonyms | IkT-148009 |
| SMILES | O=C(C1=CC=C(CN2CCN(CC2)C)C=C1)NC3=CC=C(C)C(NC4=NC(C5=CN=CC(C6=C(C)C=NO6)=C5)=CC=N4)=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.