Fig. 1 · Structure
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RJG-2051
AKR1C3 Inhibitor
RJG-2051 is a selective covalent inhibitor of aldo-keto reductase family 1 member C3 (AKR1C3), exhibiting an IC50 value of 13 nM. By inhibiting AKR1C3, RJG-2051 disrupts the metabolism of key substrates, including androgens, estrogens, and prostaglandins. This compound holds significant potential for cancer research, offering insights into therapeutic strategies targeting hormone-related pathways in tumorigenesis.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2851993-77-4 |
| Applications | AKR1C3 Inhibitor |
| Formula | C26H31N5O4S |
| Molecular Weight | 509.62 |
| SMILES | COC1=CC=CC=C1N2CCN(CC2)C(C3=CC=C(C=C3)S(=O)(N4C=NC(C5CCCCC5)=N4)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.