Fig. 1 · Structure
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RJR-2429
α4β2 Agonist
RJR-2429 is a potent agonist of the α4β2 nicotinic acetylcholine receptor (nAChR) with an EC50 value of 59 nM and a binding affinity (Ki) of 1 nM. This compound is known to induce contraction in the ileum, making it relevant for studies examining gastrointestinal motility and nAChR-mediated signaling pathways. RJR-2429 serves as a valuable tool in pharmacological research focused on neuropharmacology and cholinergic function.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 91556-75-1 |
| Applications | α4β2 Agonist |
| Formula | C12H16N2 |
| Molecular Weight | 188.27 |
| SMILES | N1(CC2)C(C3=CC=CN=C3)CC2CC1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.