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RMC-9945

RAS(ON) G12D Inhibitor

RMC-9945 is a selective, covalent inhibitor targeting the RAS(ON) G12D mutant form of KRAS. This orally active compound enhances β-Catenin/TCF transcriptional activity and demonstrates sustained disease control in preclinical models of colorectal cancer with early liver metastasis. RMC-9945 serves as a valuable tool for researching RAS-driven cancer mechanisms and potential therapeutic interventions.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2922732-38-3
Applications	RAS(ON) G12D Inhibitor
Formula	C₆₀H₈₀F₃N₁₁O₆S
Molecular Weight	1140.41
Synonyms	RM-044
SMILES	FC(F)(F)CN1[C@]([C@]2=C(N=CC(N3CCN(C4CC4)CC3)=C2)[C@H](C)OC)=C5C6=CC(C7=CSC(C[C@@H](C(N8N[C@](CCC8)([H])C(OCC(C)(C5)C)=O)=O)NC([C@@H](N9C[C@]%10(CN(CC%10)C([C@H]%11[C@@H](C%12CC%12)N%11C)=O)CC9)C(C)C)=O)=N7)=CC=C61

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.