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RNA polymerase II-IN-2

Pol II Inhibitor

RNA polymerase II-IN-2 is a potent inhibitor of RNA polymerase II, exhibiting a Ki value of 9.5 nM. This compound has demonstrated significant cytotoxicity against cancer cells, showing 2 to 5 times greater toxicity compared to α-amanitin in CHO and HEK293 cell lines. RNA polymerase II-IN-2 is valuable for research applications focused on gene expression regulation and cancer biology.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2891451-33-3
Applications	Pol II Inhibitor
Formula	C₄₁H₅₈N₁₀O₁₂S
Molecular Weight	915.02
SMILES	O=C([C@H](C(CC)CC)NC(CNC1=O)=O)NCC(N[C@@H]2C(N[C@H](C(N3C[C@@H](C[C@H]3C(N[C@H](C(N[C@H]1CC4=C(S[C@H]2C)NC5=C4C=CC=C5)=O)[C@H]([C@H](CO)O)C)=O)O)=O)CC(N)=O)=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.