Fig. 1 · Structure
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Ro 04-5595
iGluR
Ro 04-5595 is a selective antagonist targeting the NR2B subunit of the NMDA receptor. This compound demonstrates strong affinity for NR2B-enriched regions while exhibiting minimal binding in the cerebellum, making it ideal for studying NR2B-mediated pathways. Ro 04-5595 has favorable pharmacokinetic properties, with rapid uptake and clearance observed in both in vitro and in vivo studies. It is a valuable tool for research investigating neuropharmacology and the role of NMDA receptors in various neurological disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 194089-07-1 |
| Applications | iGluR |
| Formula | C19H22ClNO2 |
| Molecular Weight | 331.84 |
| SMILES | ClC1=CC=C(CCC2C3=CC(O)=C(C=C3CCN2C)OC)C=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.