Fig. 1 · Structure
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Ro 64-5229
mGlu2 Antagonist
Ro 64-5229 is a selective, non-competitive antagonist of the metabotropic glutamate receptor 2 (mGlu2). This compound has been shown to reduce the presynaptic inhibitory effects mediated by Neuroligin 1, thereby modulating synaptic transmission. Ro 64-5229 is primarily utilized in research exploring neuropharmacology, synaptic plasticity, and potential therapeutic avenues for neuropsychiatric disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 246852-46-0 |
| Applications | mGlu2 Antagonist |
| Formula | C17H19Cl2N3O |
| Molecular Weight | 352.26 |
| SMILES | ClC1=C(/C(OC2CCCCCC2)=C/N3N=CN=C3)C(Cl)=CC=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.