Ro-65-3479

Catalog No.: A61849
mGlu2/3 Antagonist
Ro-65-3479 is a selective antagonist of the metabotropic glutamate receptors mGlu2 and mGlu3. This compound effectively inhibits glutamate-induced signaling and modulates calcium channel activity. Ro-65-3479 is of particular interest in the research of disorders associated with glutamatergic dysregulation, including anxiety, schizophrenia, and neurodegenerative diseases.
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionRo-65-3479 is a selective antagonist of the metabotropic glutamate receptors mGlu2 and mGlu3. This compound effectively inhibits glutamate-induced signaling and modulates calcium channel activity. Ro-65-3479 is of particular interest in the research of disorders associated with glutamatergic dysregulation, including anxiety, schizophrenia, and neurodegenerative diseases.
Product Information
Catalog NumA61849
FormulaC8H11NO5
Molecular Weight201.18
CAS Number259134-85-5
SMILESO=C([C@@]1(N)[C@]2([H])[C@@H](C(O)=O)[C@]2([H])C[C@H]1O)O
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