Ro 67-4853 is a positive allosteric modulator (PAM) of the metabotropic glutamate receptor 1 (mGluR1), exhibiting an effective concentration (pEC50) of 7.16 for the rmGlu1a receptor. This compound interacts with the transmembrane domain of the receptor to enhance the potency of L-glutamate, thereby modulating group I mGlu receptors, including hmGlu1, rmGlu1, and rmGlu5. Ro 67-4853 is useful in research applications focused on enhancing sensory synaptic responses, particularly in models involving repetitive vibrissa stimulation.
Ro 67-4853 is a positive allosteric modulator (PAM) of the metabotropic glutamate receptor 1 (mGluR1), exhibiting an effective concentration (pEC50) of 7.16 for the rmGlu1a receptor. This compound interacts with the transmembrane domain of the receptor to enhance the potency of L-glutamate, thereby modulating group I mGlu receptors, including hmGlu1, rmGlu1, and rmGlu5. Ro 67-4853 is useful in research applications focused on enhancing sensory synaptic responses, particularly in models involving repetitive vibrissa stimulation.
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