Fig. 1 · Structure
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RO4988546
mGlu2/3 Receptor Negative Allosteric Modulator
RO4988546 is a negative allosteric modulator (NAM) of metabotropic glutamate receptors 2 and 3 (mGlu2 and mGlu3). This compound decreases the binding affinity of [3H]-LY354740 at the receptor's positive allosteric site, which impacts G protein coupling and intracellular signaling pathways. RO4988546 is valuable for research in developing antidepressants and cognitive enhancers, offering insights into therapeutic mechanisms targeting glutamatergic signaling.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 911114-85-7 |
| Applications | mGlu2/3 Receptor Negative Allosteric Modulator |
| Formula | C21H10F6N4O3S |
| Molecular Weight | 512.38 |
| SMILES | O=S(C1=CC(C#CC2=C3N=C(C=C(N3N=C2)C(F)(F)F)C4=CC=C(C=C4)C(F)(F)F)=CN=C1)(O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.