Fig. 1 · Structure
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Ro5-3335
RUNX1-CBFB Inhibitor
Ro5-3335 is a benzodiazepine that functions as a selective inhibitor of the RUNX1-CBFB interaction. By disrupting the RUNX1-CBFB complex, Ro5-3335 effectively represses RUNX1/CBFB-dependent transactivation. This compound is valuable for studying mechanisms related to core binding factor leukemias and may aid in the development of targeted therapies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 30195-30-3 |
| Applications | RUNX1-CBFB Inhibitor |
| Formula | C13H10ClN3O |
| Molecular Weight | 259.69 |
| SMILES | O=C1NC2=CC=C(Cl)C=C2C(C3=CC=CN3)=NC1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.