Fig. 1 · Structure
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RO5126946
α7 nAChR Potentiator
RO5126946 is a selective allosteric potentiator of the α7 nicotinic acetylcholine receptor (nAChR) with an EC50 of 0.06 μM for human α7 nAChR. This compound enhances synaptic transmission and positively modulates GABAergic responses by increasing peak current and elevating the frequency of spontaneous inhibitory postsynaptic currents while preserving receptor recovery from desensitization. RO5126946 is valuable for investigating cognitive deficits associated with neurodegenerative disorders such as Alzheimer's disease and psychiatric conditions including schizophrenia, as it augments the cognitive-enhancing effects of nicotine without detracting from its efficacy.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 1137233-79-4 |
| Applications | α7 nAChR Potentiator |
| Formula | C19H21ClN2O4S |
| Molecular Weight | 408.90 |
| SMILES | N(C(=O)C1=C(OC)C=CC(Cl)=C1)[C@H]2[C@@H](C2(C)C)C3=CC=C(S(N)(=O)=O)C=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.