RO5126946 is a selective allosteric potentiator of the α7 nicotinic acetylcholine receptor (nAChR) with an EC50 of 0.06 μM for human α7 nAChR. This compound enhances synaptic transmission and positively modulates GABAergic responses by increasing peak current and elevating the frequency of spontaneous inhibitory postsynaptic currents while preserving receptor recovery from desensitization. RO5126946 is valuable for investigating cognitive deficits associated with neurodegenerative disorders such as Alzheimer's disease and psychiatric conditions including schizophrenia, as it augments the cognitive-enhancing effects of nicotine without detracting from its efficacy.
RO5126946 is a selective allosteric potentiator of the α7 nicotinic acetylcholine receptor (nAChR) with an EC50 of 0.06 μM for human α7 nAChR. This compound enhances synaptic transmission and positively modulates GABAergic responses by increasing peak current and elevating the frequency of spontaneous inhibitory postsynaptic currents while preserving receptor recovery from desensitization. RO5126946 is valuable for investigating cognitive deficits associated with neurodegenerative disorders such as Alzheimer's disease and psychiatric conditions including schizophrenia, as it augments the cognitive-enhancing effects of nicotine without detracting from its efficacy.
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