Fig. 1 · Structure
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RO5488608
Glutamate Receptor 2/3 Modulator
RO5488608 is a negative allosteric modulator of metabotropic glutamate receptors 2 and 3, targeting their activity to influence neurotransmission. This compound effectively inhibits LY354740-induced intracellular calcium release, making it a valuable tool for studying the mechanisms of antidepressant action in research applications. RO5488608 may provide insights into glutamatergic signaling and its role in mood disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 1337920-46-3 |
| Applications | Glutamate Receptor 2/3 Modulator |
| Formula | C23H17F3N2O4S |
| Molecular Weight | 474.45 |
| SMILES | O=C1NC2=C(N=C(C1)C3=CC=CC(C4=CC=CC(S(=O)(O)=O)=C4)=C3)C=C(C)C(C(F)(F)F)=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.