Fig. 1 · Structure
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RO8191
IFNAR Agonist
RO8191 is an imidazonaphthyridine compound that functions as a potent agonist of the interferon (IFN) receptor, specifically targeting the IFNα/β receptor 2 (IFNAR2). This compound stimulates the expression of interferon-stimulated genes (ISGs) and promotes JAK/STAT phosphorylation, demonstrating significant antiviral activity against hepatitis C virus (HCV) and encephalomyocarditis virus (EMCV), with an IC50 of 200 nM for HCV replicon. Additionally, RO8191 acts as a cccDNA modulator, exhibiting interferon-like activity and providing anti-hepatitis B virus (HBV) effects, making it a valuable tool for research in virology and immune modulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 691868-88-9 |
| Applications | IFNAR Agonist |
| Formula | C14H5F6N5O |
| Molecular Weight | 373.21 |
| Synonyms | CDM-3008; RO4948191 |
| SMILES | FC(C1=C2C=CC3=NC(C4=NN=CO4)=CN3C2=NC(C(F)(F)F)=C1)(F)F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.