Fig. 1 · Structure
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Rogocekib
CLK Inhibitor
Rogocekib is a potent CLK2 inhibitor, exhibiting an IC50 of 1.4 nM. This compound demonstrates significant anti-tumor activity, making it valuable for cancer research. Its ability to selectively inhibit CLK2 positions Rogocekib as an important tool for investigating the role of clock proteins in various malignancies and potential therapeutic interventions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2144751-78-8 |
| Applications | CLK Inhibitor |
| Formula | C19H17FN8O2 |
| Molecular Weight | 408.39 |
| Synonyms | CTX-712 |
| SMILES | CC1=NC2=NC=C(C3=C4C(OC)=NC=NN4C=C3)C=C2N1CC5=NN=C([C@H](F)C)O5 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.