Fig. 1 · Structure
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ROS 234 dioxalate
H3 Antagonist
ROS 234 dioxalate is a potent H3 receptor antagonist with a pKB of 9.46 in Guinea-pig ileum and a pKi of 8.90 in Rat cerebral cortex. The compound demonstrates an ED50 of 19.12 mg/kg (ip) in ex vivo studies of the Rat cerebral cortex, making it a valuable tool for investigating H3 receptor-mediated processes. However, it exhibits poor central nervous system access, which may restrict its application in studies requiring central action.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 1781941-93-2 |
| Applications | H3 Antagonist |
| Formula | C17H19N5O8 |
| Molecular Weight | 421.36 |
| SMILES | O=C(O)C(O)=O.O=C(O)C(O)=O.C1(NCCCC2=CN=CN2)=NC3=CC=CC=C3N1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.