Fig. 1 · Structure
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ROS-generating agent 1
ROS Inducer
ROS-generating agent 1 is a potent reactive oxygen species (ROS) inducer that covalently modifies the Sec-498 residue of thioredoxin reductase (TrxR), leading to an increase in intracellular ROS levels. This compound effectively reduces TrxR protein levels, initiating ROS-dependent apoptosis and ferroptosis in NCI-H460 cancer cells. Due to its ability to induce oxidative stress, ROS-generating agent 1 serves as a valuable tool for cancer research and therapeutic studies targeting oxidative damage mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inducer |
| CAS Number | 2369030-41-9 |
| Applications | ROS Inducer |
| Formula | C21H15F6NO |
| Molecular Weight | 411.34 |
| SMILES | O=C1/C(CNC/C1=C\C2=CC(C(F)(F)F)=CC=C2)=C/C3=CC=CC(C(F)(F)F)=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.