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Roscovitine (Seliciclib)


CDK Inhibitor

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Catalog No. A10806

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Roscovitine 10mg A10806-10

Regular Price: $80.00

Special Price: $72.00

Roscovitine 50mg A10806-50

Regular Price: $150.00

Special Price: $135.00

Roscovitine 100mg A10806-100

Regular Price: $200.00

Special Price: $180.00

Roscovitine 200mg A10806-200

Regular Price: $360.00

Special Price: $324.00

Roscovitine (Seliciclib) 10mM * 1mL in DMSO A10806-10mM-D

Regular Price: $87.00

Special Price: $78.30

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Roscovitine (Seliciclib) is a CDK inhibitor that preferentially inhibit multiple enzyme targets including CDK2, CDK7 and CDK9.

Roscovitine (Seliciclib)

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Publications citing Adooq Products
Roscovitine (Seliciclib) Citations (1)
  • Vimal Pandey, .et al. Roscovitine effectively enhances antitumor activity of temozolomide in vitro and in vivo mediated by increased autophagy and Caspase-3 dependent apoptosis, Scientific Reports, 2019, 9, Article number: 5012

Chemical Information

Catalog Num A10806
Actions Inhibitor
M. Wt 354.5
Formula C19H26N6O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 186692-46-6
Synonyms CYC202, Seliciclib
SMILES CC[[email protected]](CO)NC1=NC2=C(C(=N1)NCC3=CC=CC=C3)N=CN2C(C)C

Biological Activity

Roscovitine (Seliciclib) is a CDK inhibitor that preferentially inhibit multiple enzyme targets including CDK2, CDK7 and CDK9.
Target Value
CDK5/p35IC50: 0.16μM
Cdc2/CyclinBIC50: 0.65μM
CDK2/CyclinAIC50: 0.7μM
CDK2/CyclinEIC50: 0.7μM
ERK2IC50: 14μM
GST-ERK1IC50: 30μM
ERK1IC50: 34μM
CDK4/CyclinD1IC50: >100μM
CDK6/CyclinD3IC50: >100μM
PKCαIC50: >100μM
PKCβ1IC50: >100μM
PKCβ2IC50: >100μM
PKCγIC50: 100μM
PKCεIC50: >100μM
PKCηIC50: >100μM
c-SrcIC50: 250μM
PKCδIC50: >1000μM
PKCζIC50: >1000μM
v-AblIC50: >1000μM


Solubility (25°C) * In vitro DMSO 71 mg/mL (200.31 mM)
Water <1 mg/mL (<1 mM)
Ethanol 6 mg/mL (16.92 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 28.21 mL 141.04 mL 282.09mL
0.5 mM 5.64 mL 28.21 mL 56.42 mL
1 mM 2.82 mL 14.1 mL 28.21 mL
5 mM 0.56 mL 2.82 mL 5.64 mL

*The above data is based on the productmolecular weight 354.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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