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Roscovitine (Seliciclib)

Roscovitine (Seliciclib)

Name: Roscovitine (Seliciclib)
Brand: Adooq Bioscience
SKU: A10806
Rating: 100 (2 reviews)

Catalog No.: A10806

CDK Inhibitor

Product Citations (2)

Roscovitine (Seliciclib) Chemical Structure

CAS NO. 186692-46-6

Roscovitine (Seliciclib) is a CDK inhibitor that preferentially inhibit multiple enzyme targets including CDK2, CDK7 and CDK9.

Availability: In stock

Package	Price	Qty
10 mg	$65.00
50 mg	$150.00
100 mg	$200.00
200 mg	$300.00
10mM * 1mL in DMSO	$60.00
Custom Size	Get quote

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Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable paper

Publications Citing Use of Adooq Roscovitine (Seliciclib)

Reiko Watanabe, .et al. Development of an In Silico Prediction Model for P-glycoprotein Efflux Potential in Brain Capillary Endothelial Cells toward the Prediction of Brain Penetration, J Med Chem, 2021, Mar 11;64(5):2725-2738 PMID: 33619967
Vimal Pandey, .et al. Roscovitine effectively enhances antitumor activity of temozolomide in vitro and in vivo mediated by increased autophagy and Caspase-3 dependent apoptosis, Scientific Reports, 2019, 9, Article number: 5012 PMID: 30899038

Biological Activity

Roscovitine (Seliciclib) is a CDK inhibitor that preferentially inhibit multiple enzyme targets including CDK2, CDK7 and CDK9.

Targets

Target	Value
CDK5/p35	IC50: 0.16μM
Cdc2/CyclinB	IC50: 0.65μM
CDK2/CyclinA	IC50: 0.7μM
CDK2/CyclinE	IC50: 0.7μM
ERK2	IC50: 14μM
GST-ERK1	IC50: 30μM
ERK1	IC50: 34μM
CDK4/CyclinD1	IC50: >100μM
CDK6/CyclinD3	IC50: >100μM
PKCα	IC50: >100μM
PKCβ1	IC50: >100μM
PKCβ2	IC50: >100μM
PKCγ	IC50: 100μM
PKCε	IC50: >100μM
PKCη	IC50: >100μM
c-Src	IC50: 250μM
PKCδ	IC50: >1000μM
PKCζ	IC50: >1000μM
v-Abl	IC50: >1000μM

Solubility *

In vitro (25°C)	DMSO	69 mg/mL (194.67 mM)
	Water	Insoluble
	Ethanol	6 mg/mL (16.92 mM)
In vivo	1% DMSO+10% Tween 80+20% N-N-dimethylacetamide+69% PEG 400	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	28.21 mL	141.04 mL	282.09 mL
0.5 mM	5.64 mL	28.21 mL	56.42 mL
1 mM	2.82 mL	14.1 mL	28.21 mL
5 mM	0.56 mL	2.82 mL	5.64 mL

*The above data is based on the productmolecular weight 354.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A10806
Actions	Inhibitor
CAS No.	186692-46-6
Formula	C19H26N6O
M. Wt	354.5
Purity	>98%
Synonyms	CYC202, Seliciclib
SMILES	CC[[email protected]](CO)NC1=NC2=C(C(=N1)NCC3=CC=CC=C3)N=CN2C(C)C
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.