Roscovitine (Seliciclib)

Catalog No.: A10806

CDK Inhibitor

Roscovitine (Seliciclib)

Roscovitine (Seliciclib) Chemical Structure

CAS NO. 186692-46-6

Roscovitine (Seliciclib) is a CDK inhibitor that preferentially inhibit multiple enzyme targets including CDK2, CDK7 and CDK9.

Availability: In stock

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10 mg
50 mg
100 mg
200 mg
10mM * 1mL in DMSO
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  • Vimal Pandey, .et al. Roscovitine effectively enhances antitumor activity of temozolomide in vitro and in vivo mediated by increased autophagy and Caspase-3 dependent apoptosis, Scientific Reports, 2019, 9, Article number: 5012

Biological Activity

Roscovitine (Seliciclib) is a CDK inhibitor that preferentially inhibit multiple enzyme targets including CDK2, CDK7 and CDK9.
Target Value
CDK5/p35IC50: 0.16μM
Cdc2/CyclinBIC50: 0.65μM
CDK2/CyclinAIC50: 0.7μM
CDK2/CyclinEIC50: 0.7μM
ERK2IC50: 14μM
GST-ERK1IC50: 30μM
ERK1IC50: 34μM
CDK4/CyclinD1IC50: >100μM
CDK6/CyclinD3IC50: >100μM
PKCαIC50: >100μM
PKCβ1IC50: >100μM
PKCβ2IC50: >100μM
PKCγIC50: 100μM
PKCεIC50: >100μM
PKCηIC50: >100μM
c-SrcIC50: 250μM
PKCδIC50: >1000μM
PKCζIC50: >1000μM
v-AblIC50: >1000μM
In vitro (25°C) DMSO 71 mg/mL (200.31 mM)
Water <1 mg/mL (<1 mM)
Ethanol 6 mg/mL (16.92 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 28.21 mL 141.04 mL 282.09 mL
0.5 mM 5.64 mL 28.21 mL 56.42 mL
1 mM 2.82 mL 14.1 mL 28.21 mL
5 mM 0.56 mL 2.82 mL 5.64 mL

*The above data is based on the productmolecular weight 354.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10806
Actions Inhibitor
M. Wt 354.5
Formula C19H26N6O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 186692-46-6
Synonyms CYC202, Seliciclib
SMILES CC[[email protected]](CO)NC1=NC2=C(C(=N1)NCC3=CC=CC=C3)N=CN2C(C)C

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