Total item
Cart Subtotal
$0.00 - Vimal Pandey, .et al. Roscovitine effectively enhances antitumor activity of temozolomide in vitro and in vivo mediated by increased autophagy and Caspase-3 dependent apoptosis, Scientific Reports, 2019, 9, Article number: 5012
Biological Activity
Roscovitine (Seliciclib) is a CDK inhibitor that preferentially inhibit multiple enzyme targets including CDK2, CDK7 and CDK9.
Targets
| Target | Value |
|---|---|
| CDK5/p35 | IC50: 0.16μM |
| Cdc2/CyclinB | IC50: 0.65μM |
| CDK2/CyclinA | IC50: 0.7μM |
| CDK2/CyclinE | IC50: 0.7μM |
| ERK2 | IC50: 14μM |
| GST-ERK1 | IC50: 30μM |
| ERK1 | IC50: 34μM |
| CDK4/CyclinD1 | IC50: >100μM |
| CDK6/CyclinD3 | IC50: >100μM |
| PKCα | IC50: >100μM |
| PKCβ1 | IC50: >100μM |
| PKCβ2 | IC50: >100μM |
| PKCγ | IC50: 100μM |
| PKCε | IC50: >100μM |
| PKCη | IC50: >100μM |
| c-Src | IC50: 250μM |
| PKCδ | IC50: >1000μM |
| PKCζ | IC50: >1000μM |
| v-Abl | IC50: >1000μM |
| In vitro (25°C) | DMSO | 71 mg/mL (200.31 mM) | |
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | 6 mg/mL (16.92 mM) | ||
| In vivo | 1% DMSO/30% polyethylene glycol/1% Tween 80 | 30 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 28.21 mL | 141.04 mL | 282.09 mL |
| 0.5 mM | 5.64 mL | 28.21 mL | 56.42 mL |
| 1 mM | 2.82 mL | 14.1 mL | 28.21 mL |
| 5 mM | 0.56 mL | 2.82 mL | 5.64 mL |
*The above data is based on the productmolecular weight 354.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10806 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 354.5 |
| Formula | C19H26N6O |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 186692-46-6 |
| Synonyms | CYC202, Seliciclib |
| SMILES | CC[[email protected]](CO)NC1=NC2=C(C(=N1)NCC3=CC=CC=C3)N=CN2C(C)C |
Datasheet
Product Tags
Product Questions
Product Questions
No Questions
You may also be interested in the following product(s)
PD 0332991 HCl (Palbociclib)
PD 0332991 HCl is an orally available pyridopyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activit…
AT7519 HCl
AT7519 is an inhibitor of multiple cyclin-dependent kinases (CDKs), which may result in cell cycle arrest, induction of apoptosis, and inhib…
NVP-LCQ195
NVP-LCQ195 is a small molecule heterocyclic inhibitor of CDK1, CDK2, CDK3 and CDK5 with IC50 of 1-42 nM.
Flavopiridol HCl
Flavopiridol HCl is an inhibitor of cyclin-dependent kinases. The (-)-cis form induces apoptosis in particular tumor cells.
P276-00
P276-00 is a novel CDK1, CDK4 and CDK9 inhibitor with IC50 of 79 nM, 63 nM and 20 nM, respectively. In Phase 2/3
Dinaciclib (SCH 727965)
Dinaciclib (SCH 727965) is a potent and selective cyclin-dependent kinase (CDK) inhibitor, selectively inhibiting CDK1, CDK2, CDK5 and CDK9 …
CVT-313
CVT-313 is a potent, selective, reversible, and ATP-competitive inhibitor of CDK2 (IC50 = 0.5 uM for Cdk2/A and Cdk2/E; 4.2 uM for Cdk1/B; 2…
AT7519
AT7519 is an inhibitor of multiple cyclin-dependent kinases (CDKs), which may result in cell cycle arrest, induction of apoptosis, and inhib…
Keywords:buy Roscovitine (Seliciclib) | Roscovitine (Seliciclib) Supplier | purchase | cost | manufacturer | order | distributor | buy 186692-46-6 | 186692-46-6 Supplier | purchase 186692-46-6 | 186692-46-6 cost | 186692-46-6 manufacturer | order 186692-46-6 | 186692-46-6 distributor
Contact information
United StatesAdooq Bioscience
Toll Free: (866) 930-6790
Fax: +1-323-606-8156
Email: [email protected]
Not your Region? View all Distributors
Adooq Quality Guarantee
We promise all products perform as described.