Roscovitine (Seliciclib)

Catalog No.: A10806

CDK Inhibitor

Roscovitine (Seliciclib)

Roscovitine (Seliciclib) Chemical Structure

CAS NO. 186692-46-6

Roscovitine (Seliciclib) is a CDK inhibitor that preferentially inhibit multiple enzyme targets including CDK2, CDK7 and CDK9.

Availability: In stock

Package Price Qty
10 mg
$65.00
50 mg
$150.00
100 mg
$200.00
200 mg
$300.00
10mM * 1mL in DMSO
$60.00
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  • Vimal Pandey, .et al. Roscovitine effectively enhances antitumor activity of temozolomide in vitro and in vivo mediated by increased autophagy and Caspase-3 dependent apoptosis, Scientific Reports, 2019, 9, Article number: 5012

Biological Activity

Roscovitine (Seliciclib) is a CDK inhibitor that preferentially inhibit multiple enzyme targets including CDK2, CDK7 and CDK9.
Targets
Target Value
CDK5/p35IC50: 0.16μM
Cdc2/CyclinBIC50: 0.65μM
CDK2/CyclinAIC50: 0.7μM
CDK2/CyclinEIC50: 0.7μM
ERK2IC50: 14μM
GST-ERK1IC50: 30μM
ERK1IC50: 34μM
CDK4/CyclinD1IC50: >100μM
CDK6/CyclinD3IC50: >100μM
PKCαIC50: >100μM
PKCβ1IC50: >100μM
PKCβ2IC50: >100μM
PKCγIC50: 100μM
PKCεIC50: >100μM
PKCηIC50: >100μM
c-SrcIC50: 250μM
PKCδIC50: >1000μM
PKCζIC50: >1000μM
v-AblIC50: >1000μM
In vitro (25°C) DMSO 69 mg/mL (194.67 mM)
Water Insoluble
Ethanol 6 mg/mL (16.92 mM)
In vivo 1% DMSO+10% Tween 80+20% N-N-dimethylacetamide+69% PEG 400 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 28.21 mL 141.04 mL 282.09 mL
0.5 mM 5.64 mL 28.21 mL 56.42 mL
1 mM 2.82 mL 14.1 mL 28.21 mL
5 mM 0.56 mL 2.82 mL 5.64 mL

*The above data is based on the productmolecular weight 354.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10806
Actions Inhibitor
CAS No. 186692-46-6
Formula C19H26N6O
M. Wt 354.5
Purity >98%
Synonyms CYC202, Seliciclib
SMILES CC[[email protected]](CO)NC1=NC2=C(C(=N1)NCC3=CC=CC=C3)N=CN2C(C)C
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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