Fig. 1 · Structure
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Rosuvastatin Sodium
HMGCR Inhibitor
Rosuvastatin Sodium is a potent competitive inhibitor of HMG-CoA reductase (HMGCR), exhibiting an IC50 of 11 nM. This compound significantly reduces low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels, contributing to cardiovascular health. In addition, Rosuvastatin Sodium has been shown to inhibit hERG current with an IC50 of 195 nM and affects the expression of mature hERG, as well as its interaction with heat shock protein 70 (Hsp70), making it useful in cardiovascular and metabolic research applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 147098-18-8 |
| Applications | HMGCR Inhibitor |
| Formula | C22H27FN3NaO6S |
| Molecular Weight | 503.52 |
| Synonyms | ZD 4522 Sodium; X-Plended Sodium; Crestor Sodium |
| SMILES | O=C(O[Na])C[C@H](O)C[C@H](O)/C=C/C1=C(C(C)C)N=C(N(C)S(=O)(C)=O)N=C1C2=CC=C(F)C=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.