Fig. 1 · Structure
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Rovalpituzumab tesirine
ADC
Rovalpituzumab tesirine is an antibody-drug conjugate (ADC) targeting DLL3, designed to deliver potent cytotoxic effects specifically to cancer cells. It comprises a Rovalpituzumab antibody linked to a pyrrolobenzodiazepine cytotoxic agent via a protease-cleavable linker. This compound has demonstrated significant potential in the research of small cell lung cancer (SCLC), providing valuable insights into targeted therapy approaches.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1613313-09-9 |
| Applications | ADC |
| Molecular Weight | 148013 (average) |
| Synonyms | SC-002 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.