Fig. 1 · Structure
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Rovanersen sodium
Antisense Oligonucleotide
Rovanersen sodium is an antisense oligonucleotide that selectively targets mutated mRNA of the huntingtin (HTT) gene, allowing for the inhibition of faulty Huntingtin protein production while sparing the healthy mRNA. This compound is essential for research into Huntington's disease, providing insights into potential therapeutic approaches and mechanisms underlying the disease pathology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2231347-41-2 |
| Applications | Antisense Oligonucleotide |
| Formula | C202H240N82Na19O111P19S13 |
| Molecular Weight | 6617 (free acid) |
| Synonyms | WVE-120101 sodium |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.