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Biological Activity
Rp-8-Br-PET-cGMPS is metabolically stable, competitive inhibitor of cGKI (Ki = 30 nM) and cGKII (cGMP-dependent protein kinase G) and blocks cGMP-gated retinal type ion channels (IC50 = 25 µM).
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.79 mL | 88.93 mL | 177.85 mL |
| 0.5 mM | 3.56 mL | 17.79 mL | 35.57 mL |
| 1 mM | 1.78 mL | 8.89 mL | 17.79 mL |
| 5 mM | 0.36 mL | 1.78 mL | 3.56 mL |
*The above data is based on the productmolecular weight 562.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A16030 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 185246-32-6 |
| Formula | C18H14BrN5NaO6PS |
| M. Wt | 562.27 |
| Purity | >98% |
| SMILES | C1C2C(C(C(O2)N3C4=C(C(=O)N5C=C(NC5=N4)C6=CC=CC=C6)N=C3Br)O)OP(=O)(O1)[S-].[Na+] |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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