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Rp-dGTPαS

SAMHD1 Substrate

Rp-dGTPαS is a nucleotide substrate for SAMHD1, which plays a critical role in regulating cellular dNTP pools and inhibiting viral replication, particularly in CD4+ myeloid cells and resting T cells. The enzyme SAMHD1, in its tetrameric form, catalyzes the hydrolysis of Rp-dGTPαS into 2'-deoxynucleosides and triphosphates, thereby affecting nucleic acid metabolism and viral clearance. This compound is valuable for studies related to HIV-1 biology and dNTP regulation in various cellular contexts.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	80902-29-0
Applications	SAMHD1 Substrate
Formula	C₁₀H₁₆N₅O₁₂P₃S
Molecular Weight	523.25
SMILES	OP(OP(O[P@@](OC[C@@H]1[C@@H](O)C[C@H](N(C=N2)C(NC(N)=N3)=C2C3=O)O1)(S)=O)(O)=O)(O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.