Fig. 1 · Structure
Documents & Downloads
RP03707
PROTAC Degrader
RP03707 is a potent PROTAC degrader targeting KRASG12D. By forming a ternary complex with KRASG12D and the CRBN E3 ligase, RP03707 facilitates the ubiquitination and subsequent proteasomal degradation of KRASG12D. This compound demonstrates significant inhibitory effects on the growth of KRASG12D-positive tumor cells, making it an essential tool for research in cancer biology and targeted therapy development.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Degrader |
| CAS Number | 3030493-05-8 |
| Applications | PROTAC Degrader |
| Formula | C55H58F3N11O4 |
| Molecular Weight | 994.12 |
| SMILES | O=C1NC(CCN1C2=NN(C)C3=C2C=C(F)C(C4CCN(C5CC6(CCN(CC7(COC8=NC9=C(C=NC(C%10=C%11C(C#C)=C(F)C=CC%11=CC(O)=C%10)=C9F)C(N%12C[C@H]%13N[C@H](CC%13)C%12)=N8)CC7)CC6)C5)CC4)=C3)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.