RS 45041-190 hydrochloride is a high-affinity ligand for I2 imidazoline receptors, exhibiting pKis of 8.66, 9.37, 9.32, and 8.85 in kidney tissues from rat, rabbit, dog, and baboon, respectively. This compound demonstrates moderate inhibitory activity against monoamine oxidase A with a pIC50 of 6.12, while its potency against monoamine oxidase B is lower, with a pIC50 of 4.47. RS 45041-190 hydrochloride is useful in studying the role of imidazoline receptors and the modulation of monoamine oxidase activity in various biological contexts.
RS 45041-190 hydrochloride is a high-affinity ligand for I2 imidazoline receptors, exhibiting pKis of 8.66, 9.37, 9.32, and 8.85 in kidney tissues from rat, rabbit, dog, and baboon, respectively. This compound demonstrates moderate inhibitory activity against monoamine oxidase A with a pIC50 of 6.12, while its potency against monoamine oxidase B is lower, with a pIC50 of 4.47. RS 45041-190 hydrochloride is useful in studying the role of imidazoline receptors and the modulation of monoamine oxidase activity in various biological contexts.
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