Fig. 1 · Structure
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RS 45041-190 hydrochloride
I2 Imidazoline Receptor Ligand
RS 45041-190 hydrochloride is a high-affinity ligand for I2 imidazoline receptors, exhibiting pKis of 8.66, 9.37, 9.32, and 8.85 in kidney tissues from rat, rabbit, dog, and baboon, respectively. This compound demonstrates moderate inhibitory activity against monoamine oxidase A with a pIC50 of 6.12, while its potency against monoamine oxidase B is lower, with a pIC50 of 4.47. RS 45041-190 hydrochloride is useful in studying the role of imidazoline receptors and the modulation of monoamine oxidase activity in various biological contexts.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 204274-74-8 |
| Applications | I2 Imidazoline Receptor Ligand |
| Formula | C11H13Cl2N3 |
| Molecular Weight | 258.15 |
| SMILES | ClC1=CC=CC2=C1CN(C3=NCCN3)C2.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.