Fig. 1 · Structure
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(RS)-4C3HPG
mGluR1 antagonist
(RS)-4C3HPG, or 4-Carboxy-3-hydroxyphenylglycine, serves as a competitive antagonist of the metabotropic glutamate receptor 1 (mGluR1) in the central nervous system and acts as an agonist at mGluR2/3. This compound demonstrates neuroprotective properties in models of acute global ischemia, making it a valuable tool for investigating glutamate receptor signaling and associated neuroprotective mechanisms. Its dual activity presents opportunities for research in neurodegenerative diseases and synaptic modulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 134052-66-7 |
| Applications | mGluR1 antagonist |
| Formula | C9H9NO5 |
| Molecular Weight | 211.17 |
| Synonyms | 4-Carboxy-3-hydroxyphenylglycine |
| SMILES | O=C(O)C(N)C1=CC=C(C(O)=O)C(O)=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.