Fig. 1 · Structure
Documents & Downloads
(RS)-4CPG
mGluR Antagonist
(RS)-4CPG ((RS)-4-Carboxyphenylglycine) is a type I metabotropic glutamate receptor antagonist that effectively inhibits the induction of long-term potentiation (LTP). In experimental models, notably in mice deficient in IP3R1, (RS)-4CPG at a concentration of 500 µM significantly blocked LTP induction. Research shows an LTP of 117.6±1.7% in IP3R1(-/-) and 116.9±1.8% in IP3R1(+/+) mice, underscoring its potential utility in studies of synaptic plasticity and neuropharmacology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 7292-81-1 |
| Applications | mGluR Antagonist |
| Formula | C9H9NO4 |
| Molecular Weight | 195.17 |
| Synonyms | (RS)-4-Carboxyphenylglycine |
| SMILES | O=C(O)C(N)C1=CC=C(C(O)=O)C=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.