(RS)-4CPG ((RS)-4-Carboxyphenylglycine) is a type I metabotropic glutamate receptor antagonist that effectively inhibits the induction of long-term potentiation (LTP). In experimental models, notably in mice deficient in IP3R1, (RS)-4CPG at a concentration of 500 µM significantly blocked LTP induction. Research shows an LTP of 117.6±1.7% in IP3R1(-/-) and 116.9±1.8% in IP3R1(+/+) mice, underscoring its potential utility in studies of synaptic plasticity and neuropharmacology.
(RS)-4CPG ((RS)-4-Carboxyphenylglycine) is a type I metabotropic glutamate receptor antagonist that effectively inhibits the induction of long-term potentiation (LTP). In experimental models, notably in mice deficient in IP3R1, (RS)-4CPG at a concentration of 500 µM significantly blocked LTP induction. Research shows an LTP of 117.6±1.7% in IP3R1(-/-) and 116.9±1.8% in IP3R1(+/+) mice, underscoring its potential utility in studies of synaptic plasticity and neuropharmacology.
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