RS-64459-193 is a selective partial agonist of the 5-HT1A receptor, exhibiting a Ki of 24.9 nM. It demonstrates substantial affinity for additional serotonin receptors, including 5-HT2C, 5-HT2A, and 5-HT7, with pKi values of 6.87, 7.02, and 7.18, respectively. RS-64459-193 is characterized by minimal activity at the 5-HT3 receptor, making it a useful tool for studies focused on serotonin signaling pathways and potential therapeutics for disorders related to serotonergic dysregulation.
RS-64459-193 is a selective partial agonist of the 5-HT1A receptor, exhibiting a Ki of 24.9 nM. It demonstrates substantial affinity for additional serotonin receptors, including 5-HT2C, 5-HT2A, and 5-HT7, with pKi values of 6.87, 7.02, and 7.18, respectively. RS-64459-193 is characterized by minimal activity at the 5-HT3 receptor, making it a useful tool for studies focused on serotonin signaling pathways and potential therapeutics for disorders related to serotonergic dysregulation.
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