Fig. 1 · Structure
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RS-79948-197
α2-Adrenoceptor Antagonist
RS-79948-197 is a non-imidazoline antagonist of the α2-adrenoceptor, demonstrating high affinity with Kd values of 0.42 nM, 0.18 nM, 0.19 nM, 0.60 nM, 0.46 nM, and 0.77 nM for rat α2A, rat α2B, rat α2C, human α2A, human α2B, and human α2C receptors, respectively. This compound is utilized in research exploring the modulation of adrenergic signaling pathways, as well as studies focused on potential therapeutic applications in cardiovascular and neurological disorders. The characterization of RS-79948-197 can provide insights into the role of α2-adrenoceptors in various physiological processes.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 186002-54-0 |
| Applications | α2-Adrenoceptor Antagonist |
| Formula | C19H29ClN2O3S |
| Molecular Weight | 400.96 |
| Synonyms | RS-79948 hydrochloride |
| SMILES | CCS(=O)(N1[C@@]2([H])C[C@@]3([H])C4=CC=C(OC)C=C4CCN3C[C@@]2([H])CCC1)=O.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.