Fig. 1 · Structure
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RS100329 hydrochloride
α1A-adrenoceptor Antagonist
RS100329 hydrochloride is a potent and selective antagonist of the α1A-adrenoceptor, exhibiting pKi values of 9.6, 7.9, and 7.5 for α1A, α1D, and α1B, respectively. This compound effectively inhibits reflex urethral contractions, making it valuable for investigating mechanisms associated with benign prostatic hyperplasia. RS100329 hydrochloride is an important tool for research focused on therapeutic strategies targeting adrenergic signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 1215654-26-4 |
| Applications | α1A-adrenoceptor Antagonist |
| Formula | C20H26ClF3N4O3 |
| Molecular Weight | 462.89 |
| SMILES | O=C1N(CCCN2CCN(C3=CC=CC=C3OCC(F)(F)F)CC2)C(C(C)=CN1)=O.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.