Fig. 1 · Structure
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RSM-932A
ChoKα Inhibitor
RSM-932A is a selective inhibitor of ChoKα, exhibiting IC50 values of 1 μM and 33 μM for human recombinant ChoKα and ChoKβ, respectively. This compound has demonstrated significant anti-proliferative effects in vitro and shows promising anti-tumor activity in vivo against human xenograft models in mice, highlighting its potential therapeutic benefits with a favorable toxicity profile. RSM-932A serves as an important tool for exploring ChoKα's role in cancer biology and evaluating targeted therapeutic strategies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 850807-63-5 |
| Applications | ChoKα Inhibitor |
| Formula | C46H38Br2Cl2N4 |
| Molecular Weight | 877.53 |
| Synonyms | TCD-717 |
| SMILES | CN(C1=C2C=CC=CC2=[N+](CC3=CC=C(C4=CC=C(C[N+]5=C6C=CC=CC6=C(N(C7=CC=C(Cl)C=C7)C)C=C5)C=C4)C=C3)C=C1)C8=CC=C(Cl)C=C8.[Br-].[Br-] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.