Fig. 1 · Structure
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RSS0680
Kinases PROTAC
RSS0680 is a small noncoding RNA (sRNA) that targets the ribosome binding site (RBS) of mRNA, functioning as a PROTAC to facilitate the degradation of various protein kinases. By competitively binding to the RBS through its conserved anti-Shine-Dalgarno sequence, RSS0680 inhibits the translation initiation of target genes. Key biological activities include the degradation of kinases such as AAK1, CDK1, and MAPK6, making it a valuable tool for investigating diseases associated with dysregulated kinase activity. Additionally, RSS0680 plays a role in bacterial oxidative stress defense and can enhance resistance to heat shock and oxidative damage by modulating metabolic pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Degrader |
| CAS Number | 2769753-48-0 |
| Applications | Kinases PROTAC |
| Formula | C52H64N10O6S3 |
| Molecular Weight | 1021.32 |
| SMILES | CS(NC1=CC=CC(C2=CSC3=CN=C(N=C23)NC4=CC=C(N5CCN(CC5)CCCCCC(N[C@@H](C(C)(C)C)C(N6[C@@H](C[C@H](C6)O)C(N[C@H](C7=CC=C(C8=C(N=CS8)C)C=C7)C)=O)=O)=O)C=C4)=C1)(=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.