Fig. 1 · Structure
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RTI 336
DAT Inhibitor
RTI 336 is a potent and selective dopamine transporter (DAT) inhibitor derived from the phenyltropane class. This compound effectively reduces locomotor activity and self-administration of addictive agents in Lewis rats, demonstrating significant inhibition linked to the intrinsic levels of DAT in the nucleus accumbens (NAc). RTI 336 serves as a valuable tool for research into the mechanisms underlying addiction and dopamine signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 204069-50-1 |
| Applications | DAT Inhibitor |
| Formula | C24H26Cl2N2O |
| Molecular Weight | 429.38 |
| SMILES | CN1[C@H]2[C@@H](C3=CC(C4=CC=C(C)C=C4)=NO3)[C@@H](C5=CC=C(Cl)C=C5)C[C@@H]1CC2.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.