Fig. 1 · Structure
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Rubone
miR-34a Modulator
Rubone is a chalcone analog that functions as a modulator of miR-34a, promoting its expression in a p53-dependent manner. This modulation results in the downregulation of key oncogenic targets, including Bcl-2 and Cyclin D1, thereby inhibiting growth in hepatocellular carcinoma (HCC) models. Additionally, Rubone enhances the efficacy of Paclitaxel in resistant prostate cancer cell lines by reversing the expression of miR-34a downstream targets, making it a valuable tool for cancer research applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 73694-15-2 |
| Applications | miR-34a Modulator |
| Formula | C20H22O7 |
| Molecular Weight | 374.38 |
| SMILES | O=C(/C=C/C1=CC(OC)=C(C=C1OC)OC)C2=C(C=C(C=C2O)OC)OC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.