Fig. 1 · Structure
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Rugonersen sodium
Antisense Oligonucleotide
Rugonersen sodium is a locked-nucleic acid (LNA)-modified antisense oligonucleotide (ASO) targeting ubiquitin-protein ligase E3A (UBE3A). This compound effectively reduces the silencing of UBE3A, making it a valuable tool for studying Angelman syndrome, a severe neurodevelopmental disorder resulting from the loss of functional UBE3A in neurons. Rugonersen sodium facilitates research into potential therapeutic strategies for this condition, contributing to the understanding of UBE3A function and regulation in neuronal development.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2591588-58-6 |
| Applications | Antisense Oligonucleotide |
| Formula | C204H235N63Na19O109P19S19 |
| Molecular Weight | 6530.3 (free acid) |
| Synonyms | RG6091 sodium; RO7248824 sodium |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.